SENSITIVE DETECTION OF PRE-EXISTING BCR-ABL KINASE DOMAIN MUTATIONS IN CD34+ CELLS OF NEWLY DIAGNOSED CHRONIC-PHASE CHRONIC MYELOID LEUKEMIA PATIENTS IS ASSOCIATED WITH IMATINIB RESISTANCE: IMPLICATIONS IN THE POST-IMATINIB ERA.

BACKGROUND: BCR-ABL kinase domain mutations are infrequently detected in newly diagnosed chronic-phase chronic myeloid leukemia (CML) patients.Recent studies indicate the presence of pre-existing BCR-ABL mutations in a higher percentage of CML patients when CD34+ stem/progenitor cells are investigated using sensitive techniques, and these mutations

With the development of marine economy, the exploitation of marine resources has gradually changed from single stereo exploitation to multi-layered stereo exploitation, and the intensity and density of exploitation have been increasing, so the marine ecological environment is facing great pressure.In order to alleviate the contradiction between the

As it is well known, digitalization of many aspects of modern society has become an urgent topic in the XXI century for most developed countries.The field of education is experiencing a rapid development of digitalization; distance learning is becoming one of the main forms.This impulsiveness has 405 caused many problems, both organizational and ps

Introduction.Yersinia enterocolitica (Ye) species is divided into 6 biotypes (BT), 1A, 1B, 2, 3, 4, 5 classified based on biochemical reactions and about 70 serotypes, classified based on Clove the structure of the lipopolysaccharide O-antigen.The BT1A is considered non-pathogenic, while the BT 1B-5 are considered pathogenic.Methods.Evaluate the di